1 EU/3/21/2558 Orphan Designation for Treatment Of Glycogen Storage Disease Type Ia
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Glycogen is just too massive a molecule to be released and journey intercellularly. In addition it seems that glycogen’s function isn't to provide vitality substrate purely for astrocytes, thus the trafficking of lactate to neural components makes sense, but does pose a few vital questions. Initial research by Pierre Magistretti’s group investigated the position of neurotransmitters and different compounds in regulating the glycogen content material. They found that glycogen was indeed up- and down regulated by such compounds (Magistretti et al., 1993b, 1994