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The exception to the rule is the DOT1 family, members of which methylate K79 within the globular region of histone H3 and which are structurally not related to SET-area proteins four - 6 Current work suggests that SET-area-containing proteins methylate a few proteins [lawyer in my area](https://knowledgekh.com/blog/index.php?entryid=185759) addition to histones (see later)
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